effects of nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial
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abstract
objectives: nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. the aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of nigella sativa oil in patients with rheumatoid arthritis (ra). materials and methods: forty-two patients with ra were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. subjects in intervention group received two capsules, 500 mg each, of nigella sativa oil, each day for 8 weeks. the other group consumed two capsules as placebo per day for the same period of time. serum tnf-α, il-10, and whole blood levels of oxidative stress parameters were measured at baseline and end of the trial. results: the serum level of il-10 was increased in the nigella sativa group (p<0.01). moreover, treatment with nigella sativa led to significant reduction of serum mda and no compared with baseline (p<0.05). there were no significant differences in the tnf-α, sod, catalase, and tas values between or within the groups, before and after the intervention (p>0.05). conclusions: this study indicates that nigella sativa could improve inflammation and reduce oxidative stress in patients with ra. it is suggested that nigella sativa may be a beneficial adjunct therapy in this population of patients
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Journal title:
avicenna journal of phytomedicineجلد ۶، شماره ۱، صفحات ۳۴-۴۳
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